As shown in Figures 3(a) and 3(b), high-fat diet feeding significantly reduced the expression of hepatic PPARγ in NASH group with the significant decreases in the percentage of PPARγ immunoreactive cells and the immunostaining intensity when compared with the control group (36.20 ± 13.51% versus 54.34 ± 5.78%, p = 0.000, and 96.17 ± 9.30 versus 107.62 ± 11.30, p = 0.042, resp). Here, PPARG is linked to metabolic dysfunction-associated steatohepatitis.