It is noteworthy that ML subgroup exhibited a relatively high hazard ratio for 5-year melanoma-specific survival (HR = 1.957; 95% CI = 1.182-3.236), as compared to tumor thickness (HR = 3.114; 95% CI = 1.647-5.888) when analyzed together, suggesting a potential interdependence between KAI1- /p27- signature and tumor thickness. The gene discussed is CDKN1B; the disease is neoplasm.