Heterogeneous and discordant AR and PSA expression in PCa cells has been reported in numerous earlier studies [39–61]; however, our study, for the first time, has proposed and presented the evidence for the 4 subtypes of PCa cells, i.e., AR+PSA+, AR−PSA+, AR+PSA−, and AR−PSA+ that pre-exist in untreated HPCa. The gene discussed is AR; the disease is posterior cortical atrophy.