Locating CAML variants that are shared globally by tissues originating from ectodermal tissues (NTC and NCC: LGG, MB, GBM, and MEL) but also distinct to the central nervous system (GBM, LGG, and MB) and further unique from breast cancer (a non-nervous system tissue) strengthens the argument for cancer cells of origin being in-part intrinsic to the ecology of tumorigenesis, cancer, and the individual. Here, CAMLG is linked to breast cancer.