Wild type p53 induced by raidation modulated MMP-2 activity, and the imbalance between MMP-2 and TIMP-2 may have an important role in glioma invasion by degradation of the ECM. For the study using mouse brain tumor model, bioluminescent U87-Fluc was useful to observe tumor formation without sacrificing animals after implanting tumor cells. This evidence concerns the gene MMP2 and brain neoplasm.