There were at least three possibilities as to what the bone lesions were: 1) a less differentiated thyroid tumor, confirmed by the relatively low level of the specific tumor marker, TG = 28 ng/mL (N.V. <0.04 ng/mL in cured thyroid cancer patients, and negative for anti-TG antibodies) determined under stimulated TSH; 2) non-avid radioiodine lesions, confirmed by the lack of radioiodine uptake, both in the bone lesions and in the shoulder mass; and 3) the absence of any relation between the bone, the muscle pathologies and the thyroid cancer. The gene discussed is TG; the disease is neoplasm.