The present study sought to dissect the molecular basis of the impressive therapeutic effects of IL-17 sequestration reported in Nguyen et al. [7], who showed that sequestration of IL-17 by using Adenoviral gene transfer to express a fusion protein called IL-17R:Fc improves function and histological metrics in the Aec1/Aec2 model of SS [7]. This evidence concerns the gene IL17A and synovial sarcoma.