With evidence accumulating that local expression of IL-17 in the salivary gland plays a detrimental role in the initiation and/or progression of SS [23], further focus on IL-17 sequestration, either through conventional pharmacotherapy (e.g., anti-IL-17 monoclonal antibodies) or gene therapy (e.g., IL-17R:Fc), appears promising. Here, IL17A is linked to synovial sarcoma.