IL17A and synovial sarcoma: Beyond the obvious need for vetting the relevance of Klk1b22 to human SS, key questions to be addressed in future studies are 1) whether IL-17 sequestration can reverse Klk1b22 expression that is already manifest, and 2) whether systemic antagonism of IL-17, such as with the newer monoclonal antibodies Secukinumab and Izekizumab, leads to the same local suppression of Klk1b22 in the salivary gland, and 3) whether IL-17 blockade ablates production of anti-Klk1b22 autoantibodies.