Then, researchers discovered that extracellular HMGB1 can be released from necrotic cells, apoptotic cells or multiple immunocompetent cells and displayed a broad spectrum of biological activities [6, 7], importantly, extracellular HMGB1 play a critical role in activation of the innate immune response, by functioning as a chemokine facilitating movement of immune cells to sites of infection, as well as in functioning as a damage-associated molecular pattern (DAMP), activating other immune cells to secrete proinflammatory cytokines, thus promoting the immune response [8]. Here, HMGB1 is linked to infection.