Hatada et al. from Japan reported that disseminated intravascular coagulation (DIC) was associated with significantly high plasma HMGB1 and the highest plasma levels of HMGB1 can be achieved 16.58 ± 11.01 ng/ml in non-survivors patients with organ failure [21]. The gene discussed is HMGB1; the disease is Disseminated intravascular coagulation.