Alternatively, the co-localization of nuclear β-catenin with intense Hmga2 staining in mouse tumors (Fig 6K–6N) could reflect Wnt signaling enhancement of Hmga2 expression, a phenomenon observed in triple-negative breast cancer, a subtype that also tends to express high LIN28B levels [9,62]. This evidence concerns the gene HMGA2 and triple-negative breast carcinoma.