Vil-Lin28bMed mice express higher levels of Lin28b, have partially depleted Let-7 miRNAs and develop adenocarcinomas of the small intestine as do Lin28bLo/Let7IEC-KO mice but do not exhibit a phenotype as severe as Lin28bLo/Let7IEC-KO mice (18). This evidence concerns the gene LIN28B and adenocarcinoma.