This was observed in a mouse model of prostatic intraepithelial neoplasia, where overexpression of Hmga2 in cancer-associated fibroblasts enhances expression of the Wnt ligands Wnt2, Wnt4, and Wnt9b, concomitant with enhanced Wnt signaling and nuclear β-catenin in adjacent neoplastic epithelium [60]. This evidence concerns the gene WNT2 and cancer.