In this latter group we find known and suspected oncogenes, such as Hmga1, Hmga2, Igf2bp1, Igf2bp2, and Mycn. As Hmga2 appeared to exhibit pronounced up-regulation (>200-fold) in the tumoroid/enteroid and tumoroid cyst populations, and increased staining in invasive areas of adenocarcinomas (Fig 3H), we evaluated Hmga2 co-localization with nuclear β-catenin in mouse tumors, to assay potential coincident activation of canonical Wnt signaling with nuclear Hmga2. The gene discussed is MYCN; the disease is adenocarcinoma.