In support of this idea, a recent study using another competitive inhibitor for the AT1R (telmisartan) in a newborn mouse model of meningitis reported that the AT1R directly associates with an E. coli outer membrane receptor indicating that E. coli invasion may depend partly on the AT1R. Moreover, this study reported that the outer membrane receptor of E. coli can induce the formation of a protein complex involving AT1R and the toll-like receptor 2 (TLR2) which could mediate bacteria invasion [42]. Here, TLR2 is linked to infectious meningitis.