NOD2 and tuberculosis: Previous studies have revealed that two isotypes of the HLA gene, HLA-DRB1*04 and HLA-DQB1*0201, are associated with TB in Chinese Kazakh [5], and have identified 17 polymorphic variants of non-HLA gene (NRAMP1, VDR, IL-10, MBP, IFN-γ, TNF-α, MMIF, BTNL2, IL-12, IL-12R, IL-10, RANTES, CCL3, MCP-1,NOS2, CR1,and NOD2) [6–15].