PDK1 and neoplasm: To sustain cellular bioenergetics and malignant growth, both hypoxia and a key transcription factor, c-Myc, promote tumor glycolysis by acting on pivotal glycolytic pathway enzymes, such as glucose transporter 1, hexokinase II, lactate dehydrogenase(LDH) and pyruvate dehydrogenase kinase 1 [27,28].