Fig 2 graphically depicts the overall diagnostic sensitivity and specificity as well as the heterogeneity across all 12 studies that investigated the diagnostic accuracy of PF NT-proBNP for HF. The overall sensitivity and specificity of blood NT-proBNP for diagnosis of HF were 0.92 and 0.88, respectively. The I2 for sensitivity and specificity were 17.48 (95% CI: 0.00–100.00) and 94.58 (95%CI: 90.85–98.32), respectively. This evidence concerns the gene NPPB and hydrops fetalis.