Histological characterization of the xenograft tumors revealed, as shown recently by us, that HBEC-KT with p53 knockdown and K-rasV12 high expression manipulation could lead to clonal derivatives with different histologies- squamous cell carcinoma (SCC, HBEC-C1) and adenocarcinoma (ADK, HBEC-C5) [31](Fig 4A). This evidence concerns the gene TP53 and adenocarcinoma.