More interestingly, adenocarcinoma type HBEC-C5 cells and tumor, but not the squamous cell carcinoma HBEC-C1, showed increased expression of Coup-TFα and β, and decreased expression of ERRα and VDR, suggesting that these four NRs might be specifically involved in adenocarcinoma type-specific lung cancer pathogenesis. The gene discussed is VDR; the disease is lung cancer.