Included in this group were AR, Coup-TFα, Coup-TFβ, dosage-sensitive sex reversal-adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX1), ERα, ERRα, HNF4γ, liver receptor homolog-1 (LRH1), NOR1, NURR1, PPARγ, RARβ, RORα, RORβ, and VDR (Fig 5A). The gene discussed is ESR1; the disease is chronic primary adrenal insufficiency.