For example, along with sumoylation, PPARγ phosphorylation could play an important role in lung cancer pathogenesis as fibroblast growth factor (FGF) activated- or cyclin-dependent kinase 5 (CDK5) phosphorylation of PPARγ revealed pathologically or physiologically altered PPARγ signaling [46–49]. The gene discussed is CDK5; the disease is lung carcinoma.