To further understand the role of IFI6 in apoptosis that was induced by DENV2-mediated infection of VECs, we constructed two stable cell lines of EA.hy926 IFI6+/+ and IFI6-/- cells, which were transfected with IFI6 over-expression (pMSCV-neo-IFI6+) and IFI6 knock-down (pMSCV-neo-IFI6-) plasmids. Here, IFI6 is linked to infection.