In this previous study, Slutter et al. (2013) also used a chimeric approach with IL-12rβ1 deficient and WT OT-1 cells to demonstrate that IL-12 receptor signaling has negative regulatory effects on CXCR3 expression during influenza priming and that this control is CD8+ T cell-intrinsic. This evidence concerns the gene CXCR3 and influenza.