Size-fractionated TG2 cross-linked in the presence of FITC labeled 33mer gluten peptide, which harbors multiple copies of the DQ2.5-glia-α2 epitope, was offered to the transduced A20 lymphoma cells and T-cell activation was assessed by IL-2 production of a T-cell hybridoma expressing T-cell receptor specific for the HLA-DQ2.5-glia-α2 epitope. The gene discussed is IL2; the disease is lymphoma.