IL10 and autoimmune disease: Indeed, the regulated functions of B10 cells are strictly related to their capacity to produce IL-10 [9, 15–18] and have been investigated in mouse models of autoimmune diseases such as contact hypersensitivity [8], lupus [19, 20], experimental autoimmune encephalomyelitis (EAE) [21–23], inflammatory bowel disease (IBD) [24, 25], and graft-versus-host disease [26].