One such study elegantly described the presence of CSCs in pancreatic cancer (PCSC) [5] and distinguished a subpopulation of PDAC cells expressing the phenotype CD44+/CD24+/ESA+ that were highly proliferative with high tumorigenic potential by comparison with the counterpart subpopulation expressing the phenotype CD44+/CD24−/ESA+ [5]. Here, CD44 is linked to familial pancreatic carcinoma.