The expression of p53 was observed in 10 of the 16 patients (62.5 %) in the SCC group and 1 of the 5 patients (20 %) in the IP + SCC group, whereas it was expressed rarely in the IP (5.9 %) and CRS (0 %, Fig. 1e) groups (Table 3). The gene discussed is TP53; the disease is incontinentia pigmenti.