SERPINA1 and intestinal disorder: There was also a significant relationship between individuals with low AAT and severity of intestinal disease, as 11 out of 15 with severe intestinal disease also had low serum AAT (p < 0.05), 5 of 6 with severe LNH also had low AAT (p < 0.05), and 5 out of 5 with severe erythema had low serum AAT (p < 0.05).