shRNA-mediated downregulation of CITED2 in the CRC cell line RKO resulted in a cell morphology change which, by phalloidin staining, was shown to affect the actin cytoskeleton, and this knockdown of CITED2 resulted in increased cellular invasiveness in a Matrigel invasion assay (Bai and Merchant 2007). This evidence concerns the gene CITED2 and colorectal carcinoma.