CITED2 and breast neoplasm: However, CITED4 (as well as CITED2) have been shown to bind and inactivate HIF-1alpha, and in breast tumors, a negative correlation exists between CITED4 and HIF-1alpha protein expression (Huang et al. 2011; Fox et al. 2004; Bhattacharya et al. 1999; Freedman et al. 2003), which would apparently contradict a role for HIF-alpha regulation of c-MET in the current study.