Additional cell lines, including a human prostate cancer cell line (PC-3), immortalized mouse aortic endothelial cells (iMAEC) and monkey kidney fibroblast (COS-7) cells were transfected with Cy3-labeled VEGF, KDR and GAPDH siRNAs by SW treatment (Supplementary Fig. 1). Here, KDR is linked to Familial prostate cancer.