M-CSF appears to be a key factor in M2 TAM differentiation, as shown by others [6, 55], but as breast cancer cell lines (MCF-7 and T47D) that do not produce M-CSF also affected the M2 phenotype, inducing M2a differentiation, we think there are other relevant M2 skewing factors, which our work cannot address. The gene discussed is CSF1; the disease is breast cancer.