The results showed the top five associated SNPs with CSS of ERBB4, NRG1 and COMT respectively, while none of the SNPs of schizophrenia associated genes COMT, ERBB4 or NRG1 was satisfied the criteria of GWAS significance threshold (Bonferroni correction P < 0.05/498,648, or i.e., ~1.0 × 10−7). The gene discussed is COMT; the disease is schizophrenia.