We analyzed CRP and a spectrum of inflammatory markers in serum from periodontitis and healthy subjects: eotaxin, MCP-1, CRP, IL-1β IL-4, IL-6, IL-10, IL-12, IL-13, IL-17, TNF-α IFN-γ, fibroblast growth factor 2 (FGF2), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage derived chemokine (MDC) and assessed their correlations to patient characteristics. This evidence concerns the gene IL4 and periodontitis.