To investigate whether defective IFN induction by pDCs contributes to the reduced IFNλ in BALF from Tpl2-/- mice during influenza infection, bone marrow-derived pDCs (CD11c+B220+CD11b-) from WT and Tpl2-/- mice were infected with influenza virus A/WSN/1933 (H1N1), and the production of IFNα, β and λ was assessed. The gene discussed is ITGAM; the disease is influenza.