More recently, Wang et al. reported that mTORC1 activates Notch3 to accelerate the development of hypoxia-induced pulmonary hypertension [30] and Karbowniczek M et al. found that mTORC1 activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development [54]. This evidence concerns the gene NOTCH3 and tuberous sclerosis.