Levels of selenium (Se) binding protein 1 (SELENBP1) expression have been shown to be higher in the dorsolateral prefrontal cortex from subjects with schizophrenia,1, 2 with the second study also showing higher levels of SELENBP1 messenger RNA (mRNA) in the dorsolateral prefrontal cortex from subjects with bipolar disorder (BP) who had psychosis,2 leading the authors to suggest that increased SELENBP1 expression may be associated with a psychotic state rather than a diagnostic criterion. This evidence concerns the gene SELENBP1 and schizophrenia.