CANX and schizophrenia: On the basis of prior findings that the α2 GABAAR subunit is expressed more highly in intact GABAARs in axosomatic synapses of pyramidal neurons in the dorsolateral prefrontal cortex in schizophrenia,60 in conjunction with our prior report demonstrating a smaller immature N-glycan attached to the α1 GABAAR subunit in schizophrenia,36 we anticipated finding increased abundance of α1 GABAAR subunits in the ER fraction, consistent with retention of this subunit in the calnexin–calreticulin protein-folding cycle, and a decreased ratio of α1:α2 GABAAR subunits in both the ER and SYN fractions.