Exercise has proven efficacious as a monotherapy as well as augmentation treatment for MDD.16, 17, 18, 19, 20 BDNF and inflammatory cytokines have been implicated in the antidepressant effects of exercise.21, 22, 23 Furthermore, exercise has been shown to reduce insomnia independent of improvement in depressive symptoms.24 The purpose of this paper is to identify biological correlates and predictors of improvements in self-reported hypersomnia and insomnia through a secondary analysis of the Treatment with Exercise Augmentation for Depression (TREAD) trial. This evidence concerns the gene BDNF and depressive disorder.