FGL2 and viral infectious disease: Our previous studies demonstrated improved DC maturation and T cell responses to LCMV WE in fgl2−/− mice versus wild-type infected mice.76 In addition to viral disease, targeted deletion of FGL2 also demonstrated improved outcomes in mice infected with Echinococcus multilocularis, a metacestode that causes alveolar echinococcis in humans and mice.96 Using mice provided by our laboratory, the authors were able to demonstrate reduced parasite loads and increased T cell responses in fgl2−/− mice.