Microarray analyses have identified that fgl2 is overexpressed in giant cell astrocytomas of the brain, as well as both low- and high-grade serous ovarian carcinomas.82 Some investigators have suggested that the prothrombinase activity of membrane-bound FGL2 is an important mediator of tumor angiogenesis and growth.83 However, two recent reports identified the immunoregulatory activity of soluble FGL2 as a key factor that inhibits the anti-tumor immune response. This evidence concerns the gene FGL2 and neoplasm.