Meningococcal infection may interact with other components of NF-κB signaling pathway including IKK complex and/or A20/TNFAIP3 to attenuate the negative feedback loop mediated by IκB [35,36,37,38] although cell lines and bacterial strains used in this study may account for these differences. Here, NFKB1 is linked to meningococcal infection.