For instance, Notch signaling pathway showed a cross-talk with multiple oncogenic signaling pathways, such as NF-κB, Akt, Sonic hedgehog (Shh), mTOR, Ras, Wnt, estrogen receptor (ER), androgen receptor (AR), epidermal growth factor receptor (EGFR), and platelet-derived growth factor (PDGF), maybe playing critical roles in tumor aggressiveness [27]. This evidence concerns the gene ESR1 and neoplasm.