The 2012 Kidney Disease: Improving Global Outcomes guidelines suggest testing for anti-erythropoietin antibodies after exposure of at least 8 weeks to an ESA, decline in hemoglobin level of >0.5 to 1.0 g/dL per week, or transfusion requirement of at least 1 to 2 units per week, normal white blood cell and platelet count, and absolute reticulocyte count <10,000/microL [9]. Here, EPO is linked to kidney disorder.