However, ALP and RUNX2 expression significantly increased in a time-dependent manner for both cells cultivated in OM and those cultivated in OM containing 100 μM Sr2+, reaching a maximum for ALP at 12 days and for RUNX2 at 18 days and both decreasing with time (Figures 5(b) and 5(d)). This evidence concerns the gene RUNX2 and ocular melanoma.