AD is the most common form of senile dementia and is characterized by senile plaque (SP) formation, which is composed of extracellularly deposited β-amyloid (Aβ) and also neurofibrillary tangles (NFT) that contain tau, which is an intracellular aggregated, hyperphosphorylated protein that belongs to the microtubule-associated protein (MAP) group [78]. The gene discussed is MAPT; the disease is Alzheimer disease.