TNFRSF25 and sarcoidosis: Figure 4a (panel c and d), and 4B showed that MMP-9 activity referable to lung T cells was not up-regulated by TL1A/DR3 interactions, whereas AMs obtained from patients with inactive sarcoidosis presented an appreciable increase of the metalloproteinase activity (3.56 ± 0.27 and 6.40 ± 1.75, in absence and presence of TL1A, respectively; p < 0.05).