As verified for MMP-9 activity, the presence of TL1A in the culture medium of AMs from patients with active sarcoidosis did not induce any variation in MMP-9 mRNA levels (9.8 ± 4.0 and 9.7 ± 3.9, in absence and presence of TL1A, respectively; p: not significant), whereas AMs recovered from patients with inactive sarcoidosis responded to TL1A stimulus, raising MMP-9 mRNA levels from 2.3 ± 0.8 to 4.3 ± 0.7 (in absence and presence of TL1A, respectively; p < 0.05). This evidence concerns the gene MMP9 and sarcoidosis.