Similarly, a real-time PCR evaluation of DR3 gene expression demonstrated that DR3 mRNA level was higher in lung CD4+ T lymphocytes (2.74 ± 1.2), and especially in AMs (9.40 ± 2.4) of active sarcoidosis than in the equivalent cell populations of patients with inactive disease (CD4+ T cells: 0.66 ± 1.2; p < 0.001 vs active disease; AMs: 4.4 ± 1.6; p < 0.01 vs active disease), and control subjects (CD4+ T cells: 0.78 ± 0.25; p < 0.001 vs active disease; AMs: 3.2 ± 2.0; p < 0.01 vs active disease). Here, TNFRSF25 is linked to sarcoidosis.