Lgr5CreERCatnblox(ex3)/+ and Lgr5CreERCatnblox(ex3)/lox(ex3) mice were induced with a single intraperitoneal injection (IP) injection of tamoxifen and rapidly developed small intesti-nal tumours (Appendix Fig S1) with similar kinetics to those following Apc deletion in the Lgr5 compartment. The gene discussed is APC; the disease is neoplasm.