In the absence of experimental work that would provide a context for the interpretation of differential microRNA expression, it is re-assuring to note that the predicted targets of differentially expressed microRNAs map to pathways that are implicated in the development and progression of diabetic kidney disease (DKD) and renal fibrosis: the growth factor TGF/FGF/PDGF/VEGF, SMAD signaling, and PI3K/AKT signaling. The gene discussed is AKT1; the disease is renal fibrosis.