Its direct function in DN is not as well understood as is its function as an adhesion receptor, regulating the neuron repulsion via an association to Sema3A and Pexin-A1 signaling co-receptor in the nervous system or as an important regulator of angiogenesis in endothelial cells through interaction with VEGF-A164/165 and VEGFR2 co-receptor complex. This evidence concerns the gene KDR and liver dysplastic nodule.