The VEGF-A/VEGFR2 complex formation is implicated in the formation and maintenance of the glomerular filtration barrier, as genetic manipulation of the Vegf-a expression in glomeruli is associated with glomerular disease in mice [84] and a podocyte-specific deletion of Vegf-a expression is characterized by impaired recruitment of the endothelial cells into glomeruli, failure of the glomerular filtration barrier formation, and congenital nephrotic syndrome [84]. Here, VEGFA is linked to glomerular disorder.