Prolonged and uncontrolled hyperglycemia contributes to an accumulation of advanced glycation end-products [4,5,6], elevated angiotensin II (ANG II) levels, hypertension [7,8], chronic inflammation, and augmented generation of profibrotic cytokines such as transforming growth factor—beta1 (TGF-β1) [9]—as well as vascular endothelial growth factor-A (VEGF-A), all of which contribute to the development of DN [10]. This evidence concerns the gene VEGFA and Hyperglycemia.