OPN-156G allele has been earlier found to have a significant association with lower diastolic function in patients with diabetes mellitus, lower risk of developing calcium urolithiasis, more rapid progression of Duchenne muscular dystrophy, susceptibility to oral squamous cell carcinoma, systemic lupus erythematosus, glioma, and T1D [15,17, 21,22,23,24,25]. The gene discussed is SPP1; the disease is oral cavity squamous cell carcinoma.