Myelin reactive CD4+ T cells secreting interferon gamma are one of many T cell mediators in the pathogenesis of MS [55], with the role of other cell types and cell subsets being also involved, with a reduction in effector function of Tregs in MS patients [56], and a key role of pro-inflammatory T helper 17 (Th17) cells emerging [48,57]. This evidence concerns the gene CD4 and myeloid sarcoma.