Remarkably, it has been reported that RNAi targeting of E7 or E6/E7 promotes the accumulation of TP53 and/or pRB, eventually leading to the induction of apoptosis and/or senescence in HPV16-positive cervical cancer cell lines [59,62,88,89], as well as in HPV18-positive human cervical cancer cells [90,91]. Here, TP53 is linked to cervical carcinoma.