However, whether non-IgE-allergic elderly AE patients with early life (childhood, adolescence, or young adulthood) onset had continuously shown a non-IgE-allergic status remains unclear, and the possibility of mild symptom status shifting to IgE-allergic elderly AE could not be ruled out for either non-IgE-allergic elderly AE patients or indeterminate-allergic elderly AE patients [8,14]. Here, IGHE is linked to acrodermatitis enteropathica.