IGHE and allergic disease: However, elderly patients with IgE-allergic AE may be speculated to have some immunological peculiarity acting against malignancy when taking into consideration findings such as the IgE-allergic reaction representing a kind of over-response against foreign substances, and the various types of immune responses other than immediate-type IgE-allergy to exclude foreign substances revealed in older patients with IgE-allergic AE [27].