In cases of IgE-allergic AE, indeterminate-allergic AE and non-IgE-allergic AE, incidences were as follows: hypertension—58.3%, 44.4%, and 53.8%; heart disease—23.7%, 33.3%, and 30.8%; spinal disease—23.7%, 11.1%, and 38.5%; cerebrovascular disease—26.3%, 7.7%, and 22.2%; diabetes mellitus—18.4%, 22.2%, and 7.7%; and chronic renal disease—10.5%, 0%, and 7.7%, respectively. The gene discussed is IGHE; the disease is cerebrovascular disorder.