A previous study suggested a strong association between filaggrin mutation of the Ichthyosis-related gene and the development of AE in IgE-allergic AE patients [13], while a tendency toward a lower incidence of ichthyosis in IgE-allergic AE compared to non-IgE-allergic AE was reported in another study [14]. The gene discussed is IGHE; the disease is ichthyosis.