Over a 10-year follow-up period, Yun et al. demonstrated that the presence of baseline macroalbuminuria (defined as urinary albumin excretion ≥300 mg/day) was an independent risk factor for future development of severe hypoglycemia in T2DM patients with apparently normal or only minimally decreased renal function (e.g., GFR >60 mL/min/1.73 m2) irrespective of whether or not they were receiving insulin [9]. This evidence concerns the gene INS and type 2 diabetes mellitus.