CRP and age-related macular degeneration: However, in a meta-analysis consisting of 11 studies (41,690 study participants) performed by Hong et al., high serum levels (>3 mg/L) of CRP were associated with a two-fold likelihood of late AMD (OR 2.189 95% CI 1.379–3.473, p = 0.001), compared to low levels (<1 mg/L) [60].