Of note, Kikuchi et al., showed that high CRP levels (>0.95 mg/dL) were associated with a three-fold risk of PCV (OR, 3.53; 95% CI, 1.49–8.40) and a four-fold risk of CNV-AMD (OR, 4.08; 95% CI, 1.94–8.56), after adjusting for age, gender, smoking status, alcohol use, body mass index, history of and use of anti-inflammatory medications [42]. Here, CRP is linked to age-related macular degeneration.