BECN1 and benign neoplasm: A novel finding of this study is Beclin-1 protein expression in 398 HGSCs, despite 76 % of these tumors harboring single-allele loss of BECN1. It is in keeping with recent immunohistochemical analyses of Beclin-1 expression that have demonstrated robust staining in ovarian carcinomas [27] greater than that seen in benign tumors or normal ovary [39, 40].