BECN1 and hepatocellular carcinoma: Furthermore, the tumor spectrum of Becn1+/− mice differs from other mouse models of autophagy disruption: Becn1+/− mice develop hepatocellular carcinomas, lung carcinomas, and lymphomas [9] whereas tissue-specific deletion of Atg7 or mosaic deletion of Atg5 led to only benign liver adenomas [49] and never the hepatocellular carcinomas seen in Becn1+/− mice.