In human biopsies of proteinuric renal disease (IgA nephropathy, minimal change disease, membranous nephropathy, and DKD), inflammasome-related proteins such as caspase 1, IL-1β and IL-18 were expressed in the distal and proximal tubules and expression positively correlated with the degree of proteinuria [127]. The gene discussed is CASP1; the disease is diabetic kidney disease.