Another model is the RPE-specific protein 65 kDA (RPE65) mutant mouse model, which is used to study Leber congenital amaurosis (LCA) and RP since the RPE 65 defect leads to a faulty isomerase which can no longer convert the chromophore necessary for rhodopsin to detect light [23]. Here, RPE65 is linked to Leber congenital amaurosis.